Article
Escherichia coli small heat shock proteins IbpA/B enhance activity of enzymes sequestered in inclusion bodies.
Acta biochimica Polonica - 1 Jan 2004
Kuczyńska-Wiśnik Dorota, Zurawa-Janicka Dorota, Narkiewicz Joanna, Kwiatkowska Joanna, Lipińska Barbara, Laskowska Ewa
Abstract excerpt
Escherichia coli small heat shock proteins, IbpA/B, function as molecular chaperones and protect misfolded proteins against irreversible aggregation. IbpA/B are induced during overproduction of recombinant proteins and bind to inclusion bodies in E. coli cells. We investigated the effect of DeltaibpA/B mutation on formation of inclusion bodies and biological activity of enzymes sequestered in the aggregates in E....
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