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Article

Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy.

Circulation research - 8 May 2009

Lombardi Raffaella, Dong Jinjiang, Rodriguez Gabriela, Bell Achim, Leung Tack Ki, Schwartz Robert J, Willerson James T, Brugada Ramon, Marian Ali J

Abstract excerpt

The phenotypic hallmark of arrhythmogenic right ventricular cardiomyopathy, a genetic disease of desmosomal proteins, is fibroadipocytic replacement of the right ventricle. Cellular origin of excess adipocytes, the responsible mechanism(s) and the basis for predominant involvement of the right ventricle are unknown. We generated 3 sets of lineage tracer mice regulated by cardiac lineage promoters alpha-myosin...

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Identifiers

PMID: 19359597
DOI: 10.1161/CIRCRESAHA.109.196899
PMCID: PMC2767296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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