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Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy

22 Sept 2021

Abstract excerpt

Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder often caused by pathogenic variants in desmosomal genes and characterized by progressive fibrotic and fat tissue accumulation in the heart. The cellular origin and responsible molecular mechanisms of fibro-fatty deposits have been a matter of debate, due to limitations in animal models recapitulating this phenotype. Here, we used human-induced...

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PMID: 34550725
DOI: 10.1126/scitranslmed.abf2750

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