APM1 gene variants -11377C/G and 4545G/C are associated respectively with obesity and with non-obesity in Chinese type 2 diabetes.

doi:10.1016/j.diabres.2009.03.004

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APM1 gene variants -11377C/G and 4545G/C are associated respectively with obesity and with non-obesity in Chinese type 2 diabetes.

Diabetes research and clinical practice - 1 Jun 2009

Wang Xizhen, Zhang Sizhong, Chen Yuanzhong, Liu Hekun, Lan Cailian, Chen Xuexiang, Chi Shuguang, Chen Suyun, Zhang Wei

Abstract excerpt

In order to explore the different genetic backgrounds of non-obese and obese type 2 diabetes, we tried to genotype six SNPs (-11391G/A, -11377C/G, -10068G/A, G54V, Y111H and 4545G/C) in the adipose most abundant gene transcript-1 (APM1) gene in 338 type 2 diabetes (T2D) patients and 460 non-diabetic subjects by PCR-RFLP. Among these mutations, the 4545G/C mutation (rs1063539) contributed to the genetic risk of...

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PMID: 19359061
DOI: 10.1016/j.diabres.2009.03.004

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