Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diastolic abnormalities as the first feature of hypertrophic cardiomyopathy in Dutch myosin-binding protein C founder mutations.

JACC. Cardiovascular imaging - 1 Jan 2009

Michels Michelle, Soliman Osama I I, Kofflard Marcel J, Hoedemaekers Yvonne M, Dooijes Dennis, Majoor-Krakauer Danielle, ten Cate Folkert J

Abstract excerpt

OBJECTIVES: To test the hypothesis that carriers of Dutch founder mutations in cardiac myosin-binding protein C (MYBPC3), without left ventricular hypertrophy (LVH) or electrocardiographic abnormalities, have diastolic dysfunction on tissue Doppler imaging (TDI), which can be used for the screening of family members in the hypertrophic cardiomyopathy (HCM) population. BACKGROUND: TDI is a more sensitive technique...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy, Hypertrophic, Familial
Share to Diastole

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Echocardiography, Doppler

Share to Hypertrophy, Left Ventricular

Share to Image Interpretation, Computer-Assisted

Share to Mass Screening

Share to Ventricular Dysfunction, Left

Share to Ventricular Function, Left

Source

Identifiers

PMID: 19356534
DOI: 10.1016/j.jcmg.2008.08.003

Genes

MYBPC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diastolic abnormalities as the first feature of hypertrophic cardiomyopathy in Dutch myosin-binding protein C founder mutations.PMID 19356534Read ↗

Subclinical echocardiographic abnormalities in phenotype-negative carriers of myosin-binding protein C3 gene mutation for hypertrophic cardiomyopathy.Semantic proximity Read ↗

Novel correlations between the genotype and the phenotype of hypertrophic and dilated cardiomyopathy: results from the German Competence Network Heart Failure.Semantic proximity Read ↗

Clinical Characteristics and Long-Term Outcome of Hypertrophic Cardiomyopathy in Individuals With a MYBPC3 (Myosin-Binding Protein C) Founder Mutation.Semantic proximity Read ↗

Hypertrophic cardiomyopathy in myosin-binding protein C (MYBPC3) Icelandic founder mutation carriers.Semantic proximity Read ↗

Long-Term Prevalence of Systolic Dysfunction in MYBPC3 Versus MYH7-Related Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

Lower left ventricular ejection time in<i>MYBPC3</i>variant carriers with overt or subclinical hypertrophic cardiomyopathySemantic proximity Read ↗

Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy.Semantic proximity Read ↗

Familial hypertrophic cardiomyopathy. Cardiac ultrasonic abnormalities in genetically affected subjects without echocardiographic evidence of left ventricular hypertrophy.Semantic proximity Read ↗

A Novel Truncating Variant in MYBPC3 Causes Hypertrophic CardiomyopathySemantic proximity Read ↗

Diastolic Dysfunction of Hypertrophic Cardiomyopathy Genotype-Positive Subjects Without Hypertrophy Is Detected by Tissue Doppler Imaging: A Systematic Review and Meta-analysis.Semantic proximity Read ↗

Cardiac myosin binding protein C and MAP-kinase activating death domain-containing gene polymorphisms and diastolic heart failure.Semantic proximity Read ↗

Early identification of mutation carriers in familial hypertrophic cardiomyopathy by combined echocardiography and tissue Doppler imaging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.