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Hydrodynamic Gene Delivery to the Liver: Theoretical and Practical Issues for Clinical Application

1 Apr 2009

Abstract excerpt

Hydrodynamic gene delivery to the liver has potential as a safe and effective approach for clinical liver gene therapy. However, the simplicity of the technique in rodents - an intravenous injection - belies the theoretical and practical complexity for clinical application. A key issue is that outflow obstruction of the DNA solution from the liver is a critical factor for raising intrahepatic vascular pressure,...

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PMID: 19355870
DOI: 10.2174/156652309787909535

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