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Article

Developmental origins of hypertrophic cardiomyopathy phenotypes: a unifying hypothesis.

Nature reviews. Cardiology - 1 Apr 2009

Olivotto Iacopo, Cecchi Franco, Poggesi Corrado, Yacoub Magdi H

Abstract excerpt

The majority of genetic mutations associated with hypertrophic cardiomyopathy (HCM) occur in genes encoding sarcomeric proteins, which are expressed only in cardiomyocytes. However, some manifestations of the HCM phenotype, such as myocardial disarray, interstitial fibrosis, mitral valve abnormalities, and microvascular remodeling, indicate the involvement of other cell lineages. The link between sarcomeric gene...

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Identifiers

PMID: 19352336
DOI: 10.1038/nrcardio.2009.9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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