[Effect of deletion mutant IPS-1 on IFN-beta induction and its antiviral to HSV-1].

Abstract excerpt

AIM: The deletion mutant gene of IFN-beta promoter stimulator 1(DeltaIPS-1) was constructed by depleting the amino acid region from 300 to 444 loci and the recombinant plasmid pEF-BOS-FLAG/DeltaIPS-1 were constructed to study the effect of deletion mutant DeltaIPS-1 to IFN-beta induction and its antiviral to HSV-1. METHODS: The mutant DeltaIPS-1 was obtained by overlap extension PCR. The depleting mutant...

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