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Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites

6 Apr 2009

Abstract excerpt

Plasmodium and Toxoplasma are parasites of major medical importance that belong to the Apicomplexa phylum of protozoa. These parasites transform into various stages during their life cycle and express a specific set of proteins at each stage. Although little is yet known of how gene expression is controlled in Apicomplexa, histone modifications, particularly acetylation, are emerging as key regulators of parasite...

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PMID: 19349466
DOI: 10.1084/jem.20082826

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