Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility HA-1Arg Null allele.

doi:10.4049/jimmunol.0803911

Article

Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility HA-1Arg Null allele.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2009

Spierings Eric, Gras Stéphanie, Reiser Jean-Baptiste, Mommaas Bregje, Almekinders Mathilde, Kester Michel G D, Chouquet Anne, Le Gorrec Madalen, Drijfhout Jan W, Ossendorp Ferry, Housset Dominique, Goulmy Els

Abstract excerpt

The di-allelic HLA-A2 restricted minor histocompatibility Ag HA-1 locus codes for the highly immunogenic HA-1(His) and the nonimmunogenic HA-1(Arg) nonapeptides, differing in one amino acid. The HA-1(His) peptide is currently used for boosting the graft-vs-tumor responses after HLA matched HA-1 mismatched stem cell transplantation; usage of the HA-1(Arg) peptide would significantly enlarge the applicability for...

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Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility HA-1Arg Null allele.

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