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Article

A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jun 2009

Scobie Linda, Hector Ralph D, Grant Louise, Bell Margaret, Nielsen Anne A, Meikle Sharon, Philbey Adrian, Philbey Adrain, Thrasher Adrian J, Thrasher Adrain J, Cameron Ewan R, Blyth Karen, Neil James C

Abstract excerpt

The emergence of leukemia following gene transfer to restore common cytokine receptor gamma chain (gammaC) function in X-linked severe combined immunodeficiency (SCID-X1) has raised important questions with respect to gene therapy safety. To explore the risk factors involved, we tested the oncoge...

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Identifiers

PMID: 19337236
DOI: 10.1038/mt.2009.59
PMCID: PMC2835181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19337236-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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