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Article

Retroviral-mediated transfer and expression of the common gamma chain into human hematopoietic progenitors.

Acta haematologica - 1 Jan 1999

Candotti F, Onodera M, Knazek R A, Blaese R M

Abstract excerpt

The common gamma chain (gammac) of cytokine receptors is mutated in X-linked severe combined immunodeficiency, a lethal disorder characterized by the absence of both humoral and cellular immune defenses. Allogeneic bone marrow transplantation from HLA-identical siblings usually results in complete reconstitution of the immune system and is the current treatment of choice. Genetic correction and reinfusion of...

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Identifiers

PMID: 10202241
DOI: 10.1159/000040932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Retroviral-mediated transfer and expression of the common gamma chain into human hematopoietic progenitors.PMID 10202241Read ↗

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Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector.Semantic proximity Read ↗

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