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The G1057D polymorphism of IRS-2 gene is not associated with type 2 diabetes and obese patients among ethnic groups in Tunisian population.

Clinical biochemistry - 1 Jul 2009

Ouederni Thouraya Baroudi, Sanchez-Corona Jose, Flores Martinez Silvia E, Ben Maiz Hedi, Skhiri Hajer Aounallah, Abid Hafaoua Kammoun, Benammar-Elgaaied Amel

Abstract excerpt

BACKGROUND: Type 2 of diabetes is the most common metabolic disorder and results from the interaction between genetic and environmental factors. Insulin receptor substrate-2 (IRS-2), one of the major substrates of the insulin receptor, has a crucial role in insulin signalling and in beta cell development and survival. While several polymorphisms have been identified in the IRS-2 gene, the association of the...

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PMID: 19332049
DOI: 10.1016/j.clinbiochem.2009.03.018

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