Article
The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice.
International immunopharmacology - 1 Jul 2009
Abe Miyuki, Funakoshi-Tago Megumi, Tago Kenji, Kamishimoto Jun, Aizu-Yokota Eriko, Sonoda Yoshiko, Kasahara Tadashi
Abstract excerpt
The somatic Jak2 mutation (V617F) was identified in most patients with polycythemia vera (PV). Here, we show that the activating Jak2 V617F mutant completely protected Ba/F3 cells from cytokine withdrawal-induced apoptotic cell death. Interestingly, Ba/F3 cells expressing Jak2 V617F mutant induced rapid tumorigenesis in nude mice, leading to rapid death. Whereas an injection of Ba/F3 cells expressing wild-type...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.