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Article

A neprilysin polymorphism and amyloid-beta plaques after traumatic brain injury.

Journal of neurotrauma - 1 Aug 2009

Johnson Victoria E, Stewart William, Graham David I, Stewart Janice E, Praestgaard Amy H, Smith Douglas H

Abstract excerpt

Traumatic brain injury (TBI) induces the rapid formation of Alzheimer's disease (AD)-like amyloid-beta (AB) plaques in about 30% of patients. However, the mechanisms behind this selective plaque formation are unclear. We investigated a potential association between amyloid deposition acutely after TBI and a genetic polymorphism of the AB-degrading enzyme, neprilysin (n = 81). We found that the length of the GT...

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Identifiers

PMID: 19326964
DOI: 10.1089/neu.2008.0843
PMCID: PMC2850253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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