Article
Changes in temperature preferences and energy homeostasis in dystroglycan mutants.
Science (New York, N.Y.) - 27 Mar 2009
Takeuchi Ken-Ichi, Nakano Yoshiro, Kato Utako, Kaneda Mizuho, Aizu Masako, Awano Wakae, Yonemura Shigenobu, Kiyonaka Shigeki, Mori Yasuo, Yamamoto Daisuke, Umeda Masato
Abstract excerpt
Temperature affects the physiology, behavior, and evolution of organisms. We conducted mutagenesis and screens for mutants with altered temperature preference in Drosophila melanogaster and identified a cryophilic (cold-seeking) mutant, named atsugari (atu). Reduced expression of the Drosophila ortholog of dystroglycan (DmDG) induced tolerance to cold as well as preference for the low temperature. A sustained...
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