Article
Granulocyte colony stimulating factor in HCV genotype-1 patients who develop Peg-IFN-alpha2b related severe neutropenia: a preliminary report on treatment, safety and efficacy.
Journal of medical virology - 1 May 2009
Koskinas John, Zacharakis George, Sidiropoulos John, Elefsiniotis John, Savvas Savvas, Kotsiou Stamatia, Kountouras Dimitrios, Schina Maria, Kostopoulos Panagiotis, Archimandritis Athanasios
Abstract excerpt
Dose reductions of Peg-IFNa because of severe neutropenia may affect the virologic response in patients with hepatitis C infection (HCV). Granulocyte colony-stimulating factor (G-CSF) has been used occasionally but studies addressing its safety and efficacy in the current treatment of HCV infection are missing. The database of 232 naïve patients with HCV genotype-1 who received PEG-IFNalpha2b 1.5 mcg/kg/week plus...
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