Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients.

doi:10.1016/j.jhep.2011.04.021

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Article

Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients.

Journal of hepatology - 1 Feb 2012

Thompson Alexander J, Clark Paul J, Singh Abanish, Ge Dongliang, Fellay Jacques, Zhu Mingfu, Zhu Qianqian, Urban Thomas J, Patel Keyur, Tillmann Hans L, Naggie Susanna, Afdhal Nezam H, Jacobson Ira M, Esteban Rafael, Poordad Fred, Lawitz Eric J, McCone Jonathan, Shiffman Mitchell L, Galler Greg W, King John W, Kwo Paul Y, Shianna Kevin V, Noviello Stephanie, Pedicone Lisa D, Brass Clifford A, Albrecht Janice K, Sulkowski Mark S, Goldstein David B, McHutchison John G, Muir Andrew J

Abstract excerpt

BACKGROUND & AIMS: Interferon-alfa (IFN)-related cytopenias are common and may be dose-limiting. We performed a genome wide association study on a well-characterized genotype 1 HCV cohort to identify genetic determinants of peginterferon-α (pegIFN)-related thrombocytopenia, neutropenia, and leukopenia. METHODS: 1604/3070 patients in the IDEAL study consented to genetic testing. Trial inclusion criteria included a...

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Identifiers

PMID: 21703177
DOI: 10.1016/j.jhep.2011.04.021
PMCID: PMC3634361

Genes

ITPA

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Source receipt: pubmed, retrieved 6 Sept 2026.

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