Article
Genetic and epigenetic analysis of recurrent hydatidiform mole.
Human mutation - 1 May 2009
Hayward Bruce E, De Vos Michel, Talati Nargese, Abdollahi M Reza, Taylor Graham R, Meyer Esther, Williams Denise, Maher Eamonn R, Setna Faridon, Nazir Kausar, Hussaini Shahnaz, Jafri Hussain, Rashid Yasmin, Sheridan Eamonn, Bonthron David T
Abstract excerpt
Familial biparental hydatidiform mole (FBHM) is a maternal-effect autosomal recessive disorder in which recurrent pregnancy failure with molar degeneration occurs. The phenotype mimics molar pregnancy due to androgenesis, despite the normal genetic makeup of the conceptus. FBHM appears to result from a failure to establish correct maternal epigenetic identity at imprinted loci during oogenesis. Several women...
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