Article
The genetics of recurrent hydatidiform moles: new insights and lessons from a comprehensive analysis of 113 patients.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2018
Nguyen Ngoc Minh Phuong, Khawajkie Yassemine, Mechtouf Nawel, Rezaei Maryam, Breguet Magali, Kurvinen Elvira, Jagadeesh Sujatha, Solmaz Asli Ece, Aguinaga Monica, Hemida Reda, Harma Mehmet Ibrahim, Rittore Cécile, Rahimi Kurosh, Arseneau Jocelyne, Hovanes Karine, Clisham Ronald, Lenzi Tiffanee, Scurry Bonnie, Addor Marie-Claude, Bagga Rashmi, Nendaz Genevieve Girardet, Finci Vildana, Poke Gemma, Grimes Leslie, Gregersen Nerine, York Kayla, Bolze Pierre-Adrien, Patel Chirag, Mozdarani Hossein, Puechberty Jacques, Scotchie Jessica, Fardaei Majid, Harma Muge, Gardner R J McKinlay, Sahoo Trilochan, Dudding-Byth Tracy, Srinivasan Radhika, Sauthier Philippe, Slim Rima
Abstract excerpt
Hydatidiform mole is an aberrant human pregnancy characterized by early embryonic arrest and excessive trophoblastic proliferation. Recurrent hydatidiform moles are defined by the occurrence of at least two hydatidiform moles in the same patient. Fifty to eighty percent of patients with recurrent hydatidiform moles have biallelic pathogenic variants in NLRP7 or KHDC3L. However, in the remaining patients, the...
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