Article
Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation.
Human genetics - 1 Oct 2006
Djuric Ugljesa, El-Maarri Osman, Lamb Barbara, Kuick Rork, Seoud Muheiddine, Coullin Philippe, Oldenburg Johannes, Hanash Samir, Slim Rima
Abstract excerpt
An imprinting disorder has been believed to underlie the etiology of familial biparental hydatidiform moles (HMs) based on the abnormal methylation or expression of imprinted genes in molar tissues. However, the extent of the epigenetic defect in these tissues and the developmental stage at which the disorder begins have been poorly defined. In this study, we assessed the extent of abnormal DNA methylation in two...
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