Article
Distinct haplogenotypes of the dopamine D2 receptor gene are associated with non-smoking behaviour and daily cigarette consumption.
Pharmacopsychiatry - 1 Mar 2009
Wernicke C, Reese J, Kraschewski A, Winterer G, Rommelspacher H, Gallinat J
Abstract excerpt
INTRODUCTION: Dopamine systems in the CNS are decisively implicated in the motivational and rewarding properties of nicotine. The dopamine D2 receptor (DRD2) plays a pivotal role by promoting these properties, making this gene a good candidate for association studies. Several single nucleotide polymorphisms (SNPs) have been described to influence the expression of DRD2. The amount of expressed DRD2 will finally...
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