Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gonadoblastoma locus and the TSPY gene on the human Y chromosome

1 Mar 2009

Abstract excerpt

The gonadoblastoma (GBY) locus is the only oncogenic locus on the human Y chromosome. It is postulated to serve a normal function in the testis, but could exert oncogenic effects in dysgenetic gonads of individuals with intersex and/or dysfunctional testicular phenotypes. Recent studies establish the testis-specific protein Y-encoded (TSPY) gene to be the putative gene for GBY. TSPY serves normal functions in...

Topics

Join the communities discussing this publication.

Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Testicular diseases and treatments
Ubiquitin and proteasome pathways

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19306348
DOI: 10.1002/bdrc.20144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gonadoblastoma locus and the TSPY gene on the human Y chromosomePMID 19306348Read ↗

Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma.Semantic proximity Read ↗

Role of the Y-located putative gonadoblastoma gene in human spermatogenesisSemantic proximity Read ↗

The chromosome Y-linked testis-specific protein locus TSPY1 is characteristically present in gonadoblastomaSemantic proximity Read ↗

The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumorsSemantic proximity Read ↗

Gonadoblastoma, testicular and prostate cancers, and the TSPY gene.Semantic proximity Read ↗

TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cellsSemantic proximity Read ↗

A Cre gene directed by a human TSPY promoter is specific for germ cells and neuronsSemantic proximity Read ↗

Presence of TSPY transcript and absence of transcripts of other Y chromosomal genes in a case of microscopic gonadoblastoma.Semantic proximity Read ↗

The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expressionSemantic proximity Read ↗

TSPY, the Candidate Gonadoblastoma Gene on the Human Y Chromosome, has a Widely Expressed Homologue on the X - Implications for Y Chromosome EvolutionSemantic proximity Read ↗

New insights into type II germ cell tumor pathogenesis based on studies of patients with various forms of disorders of sex development (DSD).Semantic proximity Read ↗

Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.