Article
Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer.
Cytogenetic and genome research - 1 Jan 2003
Lau Y-F C, Lau H W, Kömüves L G
Abstract excerpt
The contribution of specific genes on the Y chromosome in the etiology of prostate cancer has been undefined. Genetic mapping studies have identified a gonadoblastoma locus on the human Y chromosome (GBY) that predisposes the dysgenetic gonads of XY sex-reversed patients to tumorigenesis. Recently a candidate gene, the testis-specific protein Y-encoded (TSPY) that resides on the GBY critical region, has been...
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