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Article

N-acetyl cysteine (NAC)-mediated detoxification and functionalization of poly(methyl methacrylate) bone cement.

Biomaterials - 1 Jul 2009

Tsukimura Naoki, Yamada Masahiro, Aita Hideki, Hori Norio, Yoshino Fumihiko, Chang-Il Lee Masaichi, Kimoto Katsuhiko, Jewett Anahid, Ogawa Takahiro

Abstract excerpt

Currently used poly(methyl methacrylate) (PMMA)-based bone cement lacks osteoconductivity and induces osteolysis and implant loosening due to its cellular and tissue-toxicity. A high percentage of revision surgery following the use of bone cement has become a significant universal problem. This study determined whether incorporation of the amino acid derivative N-acetyl cysteine (NAC) in bone cement reduces its...

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Identifiers

PMID: 19303139
DOI: 10.1016/j.biomaterials.2009.02.043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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