Novel Osteogenic Behaviors around Hydrophilic and Radical-Free 4-META/MMA-TBB: Implications of an Osseointegrating Bone Cement.

doi:10.3390/ijms21072405

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Novel Osteogenic Behaviors around Hydrophilic and Radical-Free 4-META/MMA-TBB: Implications of an Osseointegrating Bone Cement.

International journal of molecular sciences - 31 Mar 2020

Sugita Yoshihiko, Okubo Takahisa, Saita Makiko, Ishijima Manabu, Torii Yasuyoshi, Tanaka Miyuki, Iwasaki Chika, Sekiya Takeo, Tabuchi Masako, Mohammadzadeh Rezaei Naser, Taniyama Takashi, Sato Nobuaki, Saruta Juri, Hasegawa Masakazu, Hirota Makoto, Park Wonhee, Lee Masaichi Chang-Il, Maeda Hatsuhiko, Ogawa Takahiro

Abstract excerpt

Poly(methyl methacrylate) (PMMA)-based bone cement, which is widely used to affix orthopedic metallic implants, is considered bio-tolerant but lacks osteoconductivity and is cytotoxic. Implant loosening and toxic complications are significant and recognized problems. Here we devised two strategies to improve PMMA-based bone cement: (1) adding 4-methacryloyloxylethyl trimellitate anhydride (4-META) to MMA monomer...

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PMID: 32244335
DOI: 10.3390/ijms21072405
PMCID: PMC7177939

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