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Article

Investigating unexpected INRs: in search of the culprit--adherence, interactions, genetics, and superwarfarin.

The Netherlands journal of medicine - 1 Feb 2009

Schmeits P C J, Péquériaux N C V, van Geest-Daalderop J H H, Ouwehand M E, Coremans A M J, Hermans M H A, Conemans J M H

Abstract excerpt

Treatment with coumarin derivatives is highly individualised due to high intra- and inter-individual variation in dose response and risks of severe bleeding or thromboembolic complications. Treatment focuses on reaching and maintaining a stable target international normalised ratio (INR). However, unexpected INRs that are not explained by noncompliance or vitamin K intake may occur. Here we describe seven cases...

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Identifiers

PMID: 19299851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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