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Article

Malaria primes the innate immune response due to interferon-γ induced enhancement of toll-like receptor expression and function

18 Mar 2009

Abstract excerpt

Malaria-induced sepsis is associated with an intense proinflammatory cytokinemia for which the underlying mechanisms are poorly understood. It has been demonstrated that experimental infection of humans with Plasmodium falciparum primes Toll-like receptor (TLR)-mediated proinflammatory responses. Nevertheless, the relevance of this phenomenon during natural infection and, more importantly, the mechanisms by which...

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PMID: 19297619
DOI: 10.1073/pnas.0809742106

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