Article
Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study.
Molecular psychiatry - 1 Apr 2017
Hawi Z, Cummins T D R, Tong J, Arcos-Burgos M, Zhao Q, Matthews N, Newman D P, Johnson B, Vance A, Heussler H S, Levy F, Easteal S, Wray N R, Kenny E, Morris D, Kent L, Gill M, Bellgrove M A
Abstract excerpt
Attention-deficit hyperactivity disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime outcomes. Although candidate gene and genome-wide association studies have identified promising common variant signals, these explain only a fraction of the heritability of ADHD. The observation that rare structural variants confer substantial risk to psychiatric disorders suggests that...
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