Article
Spontaneous endometrial hyperplasia in the uteri of IL-2 receptor beta-chain transgenic mice.
The Journal of reproduction and development - 1 Jun 2009
Kusakabe Ken, Kiso Yasuo, Hondo Eiichi, Takeshita Ai, Kato Keiko, Okada Toshiya, Shibata Masa-Aki, Otsuki Yoshinori
Abstract excerpt
We found frequent and spontaneous proliferation of glandular epithelium and dilated cysts in the uteri of interleukin-2 receptor (IL2R) beta-chain transgenic (Tg2Rbeta) mice. The aim of this study was to examine the involvement of IL2R beta-chain in the pathogenesis of endometrial hyperplasia (EH). Mouse uteri and serum were collected from Tg2Rbeta and normal littermates (NL), which were classified into three...
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