Article
Partial and generalized epilepsy with febrile seizures plus and a novel SCN1A mutation.
Neurology - 26 Dec 2001
Abou-Khalil B, Ge Q, Desai R, Ryther R, Bazyk A, Bailey R, Haines J L, Sutcliffe J S, George A L
Abstract excerpt
BACKGROUND: Generalized epilepsy with febrile seizures plus (GEFS+) is an autosomal dominant syndrome characterized by febrile seizures (FS) and a variety of afebrile generalized seizure types. GEFS+ has previously been linked to mutations in two genes encoding the voltage-gated sodium channel alpha-subunit (SCN1A) and beta1-subunit (SCN1B). We studied a large family with FS and partial as well as generalized...
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