Article
Genetic aspects of Alzheimer disease.
The neurologist - 1 Mar 2009
Williamson Jennifer, Goldman Jill, Marder Karen S
Abstract excerpt
BACKGROUND: Alzheimer disease (AD) is a genetically complex disorder. Mutations in 3 genes, presenilin 1, amyloid precursor protein, and presenilin 2, lead to early-onset familial AD in rare families with onset of disease occurring prior to age 65. Specific polymorphisms in apolipoprotein E are associated with the more common, late-onset AD occurring after age 65. In this review, we discuss current advances in AD...
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