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Article

Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis.

Neurochemistry international - 1 Jan 2000

Yukioka Futoshi, Matsuzaki Shinsuke, Kawamoto Keisuke, Koyama Yoshihisa, Hitomi Junichi, Katayama Taiichi, Tohyama Masaya

Abstract excerpt

In the previous reports, we showed that the familial Alzheimer's disease (AD)-linked presenilin-1 (PS1) mutation induced the fragility to the endoplasmic reticulum (ER) stress and that caspase-4 mediates ER stress-induced- and beta-amyloid induced-apoptotic signaling in human cells. These results suggest the involvement of ER stress and caspase-4 in the cell death observed in AD. In this report, we studied the...

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PMID: 17942194
DOI: 10.1016/j.neuint.2007.08.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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