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Article

Role for cumulus cell-produced EGF-like ligands during primate oocyte maturation in vitro

11 Mar 2009

Abstract excerpt

The developmental competence of in vitro-matured (IVM) rhesus macaque cumulus oocyte complexes (COCs) is deficient compared with in vivo-matured (IVM) oocytes. To improve oocyte quality and subsequent embryo development following IVM, culture conditions must be optimized. A series of experiments was undertaken to determine the role of epidermal growth factor (EGF) during IVM of rhesus macaque COCs. The addition...

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PMID: 19276391
DOI: 10.1152/ajpendo.90930.2008

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