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Epidermal growth factor enhances preimplantation developmental competence of maturing mouse oocytes

1 Dec 1999

Abstract excerpt

The objective of this study was to determine whether epidermal growth factor (EGF) promotes nuclear and cytoplasmic maturation of mouse oocytes grown in vivo or in vitro. In-vivo-grown oocytes were isolated at the germinal vesicle (GV) stage from gonadotrophin-primed (PR) or -unprimed (UPR) 22-day-old mice before in-vitro maturation (IVM). In-vitro-grown (IVG) oocytes were isolated from preantral follicles of...

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PMID: 10601097
DOI: 10.1093/humrep/14.12.3060

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