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Article

Epigenetic Regulation of c-ROS Receptor Tyrosine Kinase Expression in Malignant Gliomas

10 Mar 2009

Abstract excerpt

The proto-oncogene tyrosine kinase c-ROS is an orphan receptor whose normal expression pattern is tightly spatio-temporally restricted during development. In glioma, c-ROS mRNA expression is frequently ectopically up-regulated. In this study, we determined by immunohistochemical means that c-ROS receptor protein is present in 25% of low-grade and 30% of malignant glioma tumor samples from tissue microarrays. We...

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PMID: 19276365
DOI: 10.1158/0008-5472.can-08-3351

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