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Article

Interaction between BCL2 and interleukin-10 gene polymorphisms alter outcomes of diffuse large B-cell lymphoma following rituximab plus CHOP chemotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2009

Park Yeon Hee, Sohn Sang Kyun, Kim Jong Gwang, Lee Myung-Hoon, Song Hong Suk, Kim Min Kyoung, Jung Joo Seop, Lee Je-Joong, Kim Hyeoung Joon, Kim Dong Hwan

Abstract excerpt

PURPOSE: Rituximab may overcome bcl-2-mediated chemoresistance through the inhibition of interleukin-10 (IL-10)-mediated loops, thus down-regulating bcl-2 expression. We examined the effects of genetic variation in BCL2/IL10 gene loops on treatment outcomes of diffuse large B-cell lymphoma when treated with either CHOP or rituximab plus CHOP (R-CHOP) chemotherapy. EXPERIMENTAL DESIGN: Four genotypes were tested...

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Share to Antibodies, Monoclonal, Murine-Derived
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Doxorubicin

Share to Genes, bcl-2

Share to Lymphoma, Large B-Cell, Diffuse

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Source

Identifiers

PMID: 19276283
DOI: 10.1158/1078-0432.CCR-08-1588

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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