Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A80G polymorphism of reduced folate carrier 1 (RFC1) and C776G polymorphism of transcobalamin 2 (TC2) genes in Down's syndrome etiology.

Sao Paulo medical journal = Revista paulista de medicina - 1 Nov 2008

Biselli Joice Matos, Brumati Daniela, Frigeri Vivian Fernanda, Zampieri Bruna Lancia, Goloni-Bertollo Eny Maria, Pavarino-Bertelli Erika Cristina

Abstract excerpt

CONTEXT AND OBJECTIVE: There is evidence that polymorphisms of genes involved in folate metabolism may be associated with higher risk that mothers may bear a Down's syndrome (DS) child. This study therefore had the objective of investigating the A80G polymorphism of the reduced folate carrier 1 (RFC1) gene and the C776G polymorphism of the transcobalamin 2 (TC2) gene as maternal risk factors for DS among...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brazil
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross-Sectional Studies

Share to Down Syndrome

Share to Membrane Transport Proteins

Share to Mothers

Share to Reduced Folate Carrier Protein

Share to Transcobalamins

Source

Open in PubMed Open full text

Identifiers

PMID: 19274320
DOI: 10.1590/s1516-31802008000600007
PMCID: PMC11025994

Genes

RFC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A80G polymorphism of reduced folate carrier 1 (RFC1) and C776G polymorphism of transcobalamin 2 (TC2) genes in Down's syndrome etiology.PMID 19274320Read ↗

Investigation of CBS, MTR, RFC-1 and TC polymorphisms as maternal risk factors for Down syndrome.Semantic proximity Read ↗

Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil.Semantic proximity Read ↗

The reduced folate carrier (RFC-1) 80A>G polymorphism and maternal risk of having a child with Down syndrome: a meta-analysis.Semantic proximity Read ↗

Screening of six polymorphisms related with folate metabolism in parents of individuals with Down syndrome.Semantic proximity Read ↗

Maternal gene polymorphisms involved in folate metabolism as risk factors for Down syndrome offspring in Southern Brazil.Semantic proximity Read ↗

Maternal gene polymorphisms involved in folate metabolism and the risk of having a Down syndrome offspring: a meta-analysis.Semantic proximity Read ↗

MTHFR gene polymorphism and associated nutritional deficiency in the etiology and pathogenesis of Down syndromeSemantic proximity Read ↗

Genetic polymorphisms involved in folate metabolism and maternal risk for down syndrome: a meta-analysis.Semantic proximity Read ↗

Polymorphisms in genes RFC-1/CBS as maternal risk factors for Down syndrome in China.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase enzyme polymorphisms as maternal risk for Down syndrome among Turkish women.Semantic proximity Read ↗

Folate gene polymorphisms and the risk of Down syndrome pregnancies in young Italian women.Semantic proximity Read ↗

Maternal risk for Down syndrome is modulated by genes involved in folate metabolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.