Article
A refined characterisation of the NeoHepatocyte phenotype necessitates a reappraisal of the transdifferentiation hypothesis.
Differentiation; research in biological diversity - 1 Mar 2009
Riquelme Paloma, Wundt Judith, Hutchinson James A, Brulport Marc, Jun Yu, Sotnikova Anna, Girreser Ulrich, Braun Felix, Gövert Felix, Soria Bernat, Nüssler Andreas, Clement Bernd, Hengstler Jan G, Fändrich Fred
Abstract excerpt
Under certain culture conditions human peripheral blood monocytes may be induced to express phenotypic markers of non-haematopoietic lineages, including hepatocyte-defining traits. One such example, the NeoHepatocyte, was previously shown to express a broad panel of hepatocyte-like marker antigens and metabolic activities, both in vitro and following engraftment in the liver of immunodeficient mice. In this...
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