Article
Genetic determined downregulation of both type 1 and type 2 cytokine pathways might be protective against pancreatic cancer.
Annals of the New York Academy of Sciences - 1 Feb 2009
Scola Letizia, Giacalone Antonio, Marasà Lorenzo, Mirabile Monica, Vaccarino Loredana, Forte Giusi Irma, Giannitrapani Lydia, Caruso Calogero, Montalto Giuseppe, Lio Domenico
Abstract excerpt
Many cytokine polymorphisms have been studied for associations with susceptibility to breast, gastric, liver, lung, prostate, and ovarian cancer without conclusive results. The cytokine network, indeed, is characterized by complex interactions, and the final biological effect of a single genetic variation depends on the balance among different molecular signals. As is well known, Th1/Th2 cytokine unbalanced...
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