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Article

Therapeutic role of interleukin-1 receptor antagonist in pancreatic diseases: mendelian randomization study

14 Sept 2023

Abstract excerpt

Background The interleukin-1 pathway has been linked to pancreatic diseases. We applied the Mendelian randomization approach to explore whether higher interleukin-1 receptor antagonist (IL-1RA) levels reduce the risk of acute and chronic pancreatitis and pancreatic cancer. Methods Genetic variants associated with blood IL-1RA levels at the genome-wide significance level and located 5MB downstream or upstream of...

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Share to Genetic Associations and Epidemiology
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37781392
DOI: 10.3389/fimmu.2023.1240754

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