Article
Effects of vomitoxin ingestion on murine models for systemic lupus erythematosus.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 May 1999
Banotai C, Azcona-Olivera J I, Greene-McDowelle D M, Pestka J J
Abstract excerpt
Dietary exposure to the trichothecene vomitoxin (VT) results in reduced body weight gain, elevated serum IgA, terminal differentiation of Peyer's patch B cells to IgA secreting plasma cells haematuria, and increased kidney mesangial IgA accumulation in B6C3F1 mice and other inbred strains. These effects closely mimic a human autoimmune-like kidney disease known as IgA nephropathy. Using NZBW/F1, MRL/lpr, and BXSB...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.