Article
Automated image-based phenotypic analysis in zebrafish embryos.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2009
Vogt Andreas, Cholewinski Andrzej, Shen Xiaoqiang, Nelson Scott G, Lazo John S, Tsang Michael, Hukriede Neil A
Abstract excerpt
Presently, the zebrafish is the only vertebrate model compatible with contemporary paradigms of drug discovery. Zebrafish embryos are amenable to automation necessary for high-throughput chemical screens, and optical transparency makes them potentially suited for image-based screening. However, the lack of tools for automated analysis of complex images presents an obstacle to using the zebrafish as a...
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