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Article

Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function.

Proceedings of the National Academy of Sciences of the United States of America - 10 Mar 2009

Osborne Suzanne E, Walthers Don, Tomljenovic Ana M, Mulder David T, Silphaduang Uma, Duong Nancy, Lowden Michael J, Wickham Mark E, Waller Ross F, Kenney Linda J, Coombes Brian K

Abstract excerpt

The acquisition of DNA by horizontal gene transfer enables bacteria to adapt to previously unexploited ecological niches. Although horizontal gene transfer and mutation of protein-coding sequences are well-recognized forms of pathogen evolution, the evolutionary significance of cis-regulatory mutations in creating phenotypic diversity through altered transcriptional outputs is not known. We show the significance...

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Share to Adaptation, Physiological
Share to Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Regulatory Sequences, Nucleic Acid

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Source

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Identifiers

PMID: 19234126
DOI: 10.1073/pnas.0811669106
PMCID: PMC2645909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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