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Next-Generation Sequencing of Plasma/Serum DNA: An Emerging Research and Molecular Diagnostic Tool

22 Feb 2009

Abstract excerpt

Over the past decade, it has been increasingly realized that cell-free DNA and RNA molecules present in plasma and serum are valuable molecular diagnostic tools(1)(2). For example, tumor-derived(3) and fetal-derived(4) nucleic acids have been found in cancer patients and pregnant women, respectively, thus opening up clinical uses in oncology and prenatal diagnosis. A number of these applications have already been...

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PMID: 19233905
DOI: 10.1373/clinchem.2009.123661

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