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Article

[Role of oxidative stress in the pathophysiology of neuropsychiatric disorders].

Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica - 1 Jan 2014

Nunomura Akihiko, Tamaoki Toshio, Motohashi Nobutaka

Abstract excerpt

The brain is particularly vulnerable to oxidative damage because of its high rate of oxygen consumption, abundant lipid content, and relative paucity of antioxidant enzymes compared with other organs. It has been well established that oxidative stress (OS) is involved in the pathogenesis of age-associated neurodegenerative disorders such as Alzheimer's disease (AD). Indeed, a large number of genetic and...

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PMID: 25672211

Genes

DISC1
NRG1
PRODH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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