Article
Analysis of fetal blood using capillary electrophoresis system: a simple method for prenatal diagnosis of severe thalassemia diseases.
European journal of haematology - 1 Jul 2009
Srivorakun Hataichanok, Fucharoen Goonnapa, Sae-Ung Nattaya, Sanchaisuriya Kanokwan, Ratanasiri Thawalwong, Fucharoen Supan
Abstract excerpt
INTRODUCTION: Prenatal diagnosis of severe alpha- and beta-thalasssemia diseases is usually performed by DNA analysis. OBJECTIVE: To establish a simple method, we have evaluated the reliability of prenatal diagnosis by fetal blood analysis using automated capillary electrophoresis system. METHODS: Forty-seven fetal blood specimens collected by cordocentesis at 18-28 wk of gestation were analyzed by the capillary...
Topics
- Adult
- Cordocentesis
- DNA
- Electrophoresis, Capillary
- Female
- Fetal Blood
- Fetal Hemoglobin
- Genotype
- Hemoglobin A
- Hemoglobin E
- Hemoglobins, Abnormal
- Humans
- Male
- Polymerase Chain Reaction