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Article

Influence of squalene on lipid particle/droplet and membrane organization in the yeast Saccharomyces cerevisiae.

Biochimica et biophysica acta - 1 Apr 2012

Spanova Miroslava, Zweytick Dagmar, Lohner Karl, Klug Lisa, Leitner Erich, Hermetter Albin, Daum Günther

Abstract excerpt

In a previous study (Spanova et al., 2010, J. Biol. Chem., 285, 6127-6133) we demonstrated that squalene, an intermediate of sterol biosynthesis, accumulates in yeast strains bearing a deletion of the HEM1 gene. In such strains, the vast majority of squalene is stored in lipid particles/droplets together with triacylglycerols and steryl esters. In mutants lacking the ability to form lipid particles, however,...

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Identifiers

PMID: 22342273
DOI: 10.1016/j.bbalip.2012.01.015
PMCID: PMC3790963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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