Article
Genetically characterized positive control cell lines derived from residual clinical blood samples.
Clinical chemistry - 1 Nov 2005
Bernacki Susan H, Beck Jeanne C, Stankovic Ana K, Williams Laurina O, Amos Jean, Snow-Bailey Karen, Farkas Daniel H, Friez Michael J, Hantash Feras M, Matteson Karla J, Monaghan Kristin G, Muralidharan Kasinathan, Pratt Victoria M, Prior Thomas W, Richie Kristy L, Levin Barbara C, Rohlfs Elizabeth M, Schaefer Frederick V, Shrimpton Antony E, Spector Elaine B, Stolle Catherine A, Strom Charles M, Thibodeau Stephen N, Cole Eugene C, Goodman Barbara K, Stenzel Timothy T
Abstract excerpt
BACKGROUND: Positive control materials for clinical diagnostic molecular genetic testing are in critically short supply. High-quality DNA that closely resembles DNA isolated from patient specimens can be obtained from Epstein-Barr virus (EBV)-transformed peripheral blood lymphocyte cell lines. Here we report the development of a process to (a) recover residual blood samples with clinically important mutations...
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