Progestins Both Stimulate and Inhibit Breast Cancer Cell Cycle Progression while Increasing Expression of Transforming Growth Factor α, Epidermal Growth Factor Receptor, c- fos, and c- myc Genes

Abstract excerpt

This study documents a biphasic change in the rate of cell cycle progression and proliferation of T-47D human breast cancer cells treated with synthetic progestins, consisting of an initial transient acceleration in transit through G1, followed by cell cycle arrest and growth inhibition. Both components of the response were mediated via the progesterone receptor. The data are consistent with a model in which the...